Cell proliferation in fibrocystic disease and postmenopausal breast ducts measured by thymidine labeling
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چکیده
منابع مشابه
Cell proliferation in rat colon measured with bromodeoxyuridine, proliferating cell nuclear antigen, and [3H]thymidine.
Epithelial cell proliferation was studied in the normal colonic mucosa of 5-week-old Sprague-Dawley rats, comparing [3H]thymidine incorporation (group 1) with two newer proliferation markers, bromodeoxyuridine (group 2) and proliferating cell nuclear antigen (group 3). Microautoradiography (group 1) or immunoperoxidase assays (groups 2 and 3) were carried out. Cells were counted for positive re...
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Background: Fibrocystic disease of the breast in one of the commonest diseases in women above 30 years of age. The assumption of it being innocuous and benign is questionable with increased incidence of malignancies developing in these women. Introduction: Understanding the pathophysiology of fibrocystic disease is essential for identifying determinants of malignant change. Case Report: A case ...
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UNLABELLED The use of radiolabeled thymidine (TdR) and thymidine analogs as PET-based tracers of tumor growth rate is based on the assumption that measurement of uptake of these nucleosides, a function primarily of thymidine kinase-1 (TK(1)) activity, provides an accurate measure of active cell proliferation in tumors. The goal of this study was to test this hypothesis and determine how well th...
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متن کاملEffect of tritiated thymidine on cell proliferation.
The effect of tritiated thymidine on the rate of entry of cells into mitosis was studied in mice; 1-5 /tc of tritiated thymidine (specific activity 5 c/mM) per g body weight did not alter the rate of entry. Other workers have reported an increased number of mitoses following administration of larger amounts of thymidine than those used in the present work; the suggestion is therefore made that ...
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ژورنال
عنوان ژورنال: Cancer
سال: 1982
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(19820815)50:4<746::aid-cncr2820500420>3.0.co;2-a